low binding affinity
[loʊ ˈbaɪndɪŋ əˈfɪnəti]
noun phrase
baixa afinidade de ligação
1. A biochemical condition where a ligand (such as a drug, hormone, or protein) binds weakly to a receptor or binding site, with a higher dissociation constant (Kd) value, indicating lower stability of the binding complex
The new compound showed low binding affinity to the target protein, requiring higher concentrations to achieve therapeutic effects.
O novo composto apresentou baixa afinidade de ligação à proteína-alvo, exigindo concentrações mais elevadas para alcançar efeitos terapêuticos.
2. In molecular biology and pharmacology, a characteristic of interactions where the ligand-receptor complex dissociates rapidly, resulting in a shorter duration of binding
Compounds with low binding affinity may be preferable in some cases to avoid prolonged side effects.
Compostos com baixa afinidade de ligação podem ser preferíveis em alguns casos para evitar efeitos colaterais prolongados.
This is a technical scientific term used primarily in pharmaceutical research, biochemistry, and molecular biology. It is equally understood in both Brazilian and American scientific communities, with no regional variation in usage or meaning. The term is essential in drug development discussions where binding affinity directly impacts drug efficacy and dosing requirements.
Look up more words on Fala2Me
The free English-Portuguese dictionary with real Brazilian accents, NYC slang, conjugator and more
Open Fala2Me →