Kd value
[kay-dee ˈvæl.juː]
nounpl: Kd values
valor de Kd
1. A quantitative measure of the binding affinity between two molecules, expressing the dissociation constant in biochemistry and molecular biology. Lower Kd values indicate stronger binding.
The Kd value of the enzyme-substrate complex was determined to be 5 micromolar.
O valor de Kd do complexo enzima-substrato foi determinado em 5 micromolar.
2. In pharmacology, a measure of how strongly a drug binds to its target receptor or protein.
A drug with a lower Kd value has higher affinity for the target protein.
Um fármaco com um valor de Kd menor tem maior afinidade pela proteína alvo.
3. The concentration of ligand at which half of the binding sites are occupied at equilibrium.
The Kd value represents the ligand concentration at 50% saturation.
O valor de Kd representa a concentração de ligante em 50% de saturação.
This is specialized scientific terminology used in biochemistry, molecular biology, pharmacology, and related fields. It is understood uniformly across English and Portuguese-speaking scientific communities. The term is primarily used in academic and research settings rather than in casual conversation.
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