low affinity
[loʊ əˈfɪnəti]
noun phrase / adjective phrase
baixa afinidade
1. A weak or reduced binding interaction between two molecules, proteins, or chemical entities; characterized by a high dissociation constant (Kd) or low association constant (Ka)
The antibody showed low affinity for the antigen, requiring higher concentrations to achieve binding.
O anticorpo apresentou baixa afinidade pelo antígeno, exigindo concentrações mais altas para alcançar a ligação.
2. In chemistry and biochemistry, the reluctance or weakness with which a receptor binds to its ligand
The drug exhibited low affinity for the target protein, making it less effective at therapeutic doses.
O medicamento exibiu baixa afinidade pela proteína alvo, tornando-o menos eficaz em doses terapêuticas.
3. A general lack of attraction, preference, or compatibility between entities
There is low affinity between these two chemical compounds, so they rarely interact.
Há baixa afinidade entre esses dois compostos químicos, portanto raramente interagem.
This is primarily technical scientific terminology used in biochemistry, pharmacology, immunology, and molecular biology fields. It is not subject to regional variation and is universally understood in academic and pharmaceutical contexts in both Brazil and Portugal. The term is essential in drug development and protein interaction studies.
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