1. a path, way, or course of travel that one has not traveled before or does not know well
Taking an unfamiliar route through the city, I got lost.
Ao seguir uma rota desconhecida pela cidade, me perdi.
2. a direction or method of approach that is new or unknown to someone
The hiking guide warned us about the unfamiliar route ahead.
O guia de caminhada nos advertiu sobre a rota desconhecida à frente.