robust binding affinity
[rə-ˈbəst ˈbīn-diŋ ə-ˈfi-nə-tē]
noun phrasepl: robust binding affinities
afinidade de ligação robusta
1. In biochemistry and molecular biology, the strong and stable interaction between a ligand (such as a drug or protein) and its target binding site, characterized by a low dissociation constant (Kd) and resistance to disruption
The monoclonal antibody demonstrated robust binding affinity for the tumor antigen, making it an effective therapeutic candidate.
O anticorpo monoclonal demonstrou afinidade de ligação robusta pelo antígeno tumoral, tornando-o um candidato terapêutico eficaz.
2. A measure of the strength and consistency with which a molecule binds to its target under various conditions
Researchers selected compounds with robust binding affinity that remained stable across different pH levels.
Os pesquisadores selecionaram compostos com afinidade de ligação robusta que permaneceram estáveis em diferentes níveis de pH.
This is specialized scientific terminology primarily used in pharmaceutical research, biochemistry, and molecular biology contexts. It is equally recognized in both Brazilian and Portuguese scientific communities, as well as in international research. The term reflects the globalized nature of modern scientific communication, where English terminology is prevalent even in Portuguese-speaking research institutions.
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