1. The primary or most important path, route, or course taken to reach a destination
The main route to the city center was closed due to construction.
O percurso principal para o centro da cidade estava fechado devido às obras.
2. In transportation or navigation, the principal itinerary or path regularly followed
Bus drivers follow the main route every day at scheduled times.
Os motoristas de ônibus seguem o percurso principal todos os dias nos horários programados.
3. The dominant or preferred course of action or journey in a process or career
His main career path led him to become a successful engineer.
Seu percurso principal na carreira o levou a se tornar um engenheiro bem-sucedido.