modified nucleoside
[ˈmɒdɪfaɪd ˈnjuːkliəˌsaɪd]
nounpl: modified nucleosides
nucleosídeo modificado
1. A nucleoside that has been chemically altered from its natural form, typically by adding or removing functional groups, used in pharmaceuticals, molecular biology, and synthetic biology
Modified nucleosides are essential components in the development of mRNA vaccines.
Nucleosídeos modificados são componentes essenciais no desenvolvimento de vacinas de mRNA.
2. A purine or pyrimidine base linked to a five-carbon sugar (ribose or deoxyribose) with structural modifications that enhance stability, bioavailability, or biological activity
The modified nucleoside was designed to resist enzymatic degradation.
O nucleosídeo modificado foi projetado para resistir à degradação enzimática.
This is a technical term primarily used in scientific and pharmaceutical contexts. It became particularly prominent in global discourse following the development of COVID-19 mRNA vaccines (Pfizer-BioNTech and Moderna), which utilized modified nucleosides to improve vaccine efficacy and safety. The term is used identically in both Brazilian and American scientific communities, reflecting the international nature of biotechnology research.
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