misaligned replication
[mɪs.əˈlaɪnd ˌrɛp.lɪˈkeɪ.ʃən]
nounfemininepl: misaligned replications / replicações desalinhadas
replicação desalinhada
1. A molecular biology phenomenon where DNA polymerase incorrectly positions template and newly synthesized DNA strands during replication, causing errors in base pairing and potentially leading to mutations
Misaligned replication at the repetitive DNA sequences led to a frameshift mutation in the gene.
A replicação desalinhada nas sequências de DNA repetitivas resultou em uma mutação de mudança de quadro de leitura no gene.
2. The improper alignment of DNA strands during the replication process, typically occurring in regions with tandem repeats or homologous sequences
Misaligned replication is a common cause of trinucleotide repeat expansion disorders.
A replicação desalinhada é uma causa comum de distúrbios de expansão de repetições trinucleotídicas.
This term is primarily used in academic and research contexts within molecular biology, genetics, and medical genetics fields. It is particularly important in understanding genetic diseases related to trinucleotide repeat expansions such as Huntington's disease, Fragile X syndrome, and myotonic dystrophy. The concept is equally referenced in both Brazilian and Portuguese scientific communities, with the terminology being virtually identical.
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