frameshift mutation
[freɪmʃɪft mjuːˈteɪʃən]
nounpl: frameshift mutations
mutação de deslocamento do quadro de leitura
1. A genetic mutation caused by the insertion or deletion of nucleotides in a DNA sequence that is not a multiple of three, causing a shift in the reading frame and resulting in the production of incorrect amino acids downstream of the mutation
A frameshift mutation can completely alter the amino acid sequence of a protein, often resulting in a non-functional protein.
Uma mutação de deslocamento do quadro de leitura pode alterar completamente a sequência de aminoácidos de uma proteína, frequentemente resultando em uma proteína não funcional.
2. A type of point mutation involving the loss or gain of nucleotide base pairs that shifts the codon reading frame
The frameshift mutation introduced a premature stop codon, truncating the protein.
A mutação de deslocamento introduziu um códon de parada prematuro, truncando a proteína.
This is a specialized scientific term primarily used in genetics, molecular biology, and medical research contexts in both Brazil and the United States. It is not commonly used in everyday conversation and is mainly encountered in academic, research, and clinical settings. The term is standardized across Portuguese-speaking scientific communities.
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