1. A significant work, achievement, or product that represents substantial artistic, intellectual, or creative accomplishment
Picasso's Guernica is considered one of his major creations.
Guernica de Picasso é considerada uma de suas grandes criações.
2. An important invention or innovative development that has substantial impact
The internet was a major creation of the late 20th century.
A internet foi uma grande criação do final do século XX.
3. A masterpiece or outstanding work in any field of human endeavor
Shakespeare's Hamlet is regarded as a major creation in literature.
Hamlet de Shakespeare é considerada uma grande criação na literatura.