genome instability
[ˈdʒiːnoʊm ɪnˈsteɪbɪlɪti]
nounpl: genome instabilities
instabilidade genômica
1. The tendency of a genome to undergo frequent alterations in its DNA sequence, structure, or chromosome organization, leading to increased mutation rates and genomic rearrangements
Genome instability is a hallmark of cancer cells, driving their evolution and adaptation.
A instabilidade genômica é uma característica das células cancerosas, impulsionando sua evolução e adaptação.
2. A condition characterized by abnormal changes in the number or structure of chromosomes and genes within a cell
Researchers discovered that the mutation in the DNA repair gene caused genome instability in the patient's cells.
Os pesquisadores descobriram que a mutação no gene de reparo do DNA causou instabilidade genômica nas células do paciente.
3. The increased frequency of genetic alterations that accumulate during cell division, often resulting in chromosomal aberrations
Genome instability can accelerate tumorigenesis and the development of metastatic cancers.
A instabilidade genômica pode acelerar a tumorigênese e o desenvolvimento de cânceres metastáticos.
Genome instability is a technical term primarily used in scientific, medical, and oncological contexts in both Brazil and the United States. It gained prominence in cancer research and genetics following advances in molecular biology in the late 20th century. The term reflects the globalized nature of scientific discourse, with identical concepts used across Portuguese-speaking and English-speaking academic communities.
Look up more words on Fala2Me
The free English-Portuguese dictionary with real Brazilian accents, NYC slang, conjugator and more
Open Fala2Me →