genetic instability
[jə-ˈne-tik ˌin(t)-stə-ˈbi-lə-tē]
nounpl: genetic instabilities
instabilidade genética
1. The tendency of an organism's DNA to undergo changes, mutations, or rearrangements at a higher than normal rate, often leading to alterations in gene sequences and chromosomal structure
The cancer cells exhibited genetic instability, which accelerated tumor progression.
As células cancerígenas apresentavam instabilidade genética, o que acelerou a progressão do tumor.
2. A characteristic of genomes that lose their structural and functional integrity over time due to defects in DNA repair mechanisms
Genetic instability in the patient's cells was caused by mutations in DNA repair genes.
A instabilidade genética nas células do paciente foi causada por mutações em genes de reparo de DNA.
3. A hallmark of malignant transformation where chromosomal aberrations and point mutations accumulate at elevated frequencies
Researchers observed genetic instability in the precancerous lesions.
Os pesquisadores observaram instabilidade genética nas lesões pré-cancerosas.
This is a specialized scientific and medical term used primarily in academic, research, and clinical contexts in both Brazil and the United States. It is essential terminology in oncology, genetics, and molecular biology. The term maintains identical usage across Portuguese-speaking countries and is not subject to colloquial variation. Understanding genetic instability is crucial in cancer research and personalized medicine in both cultures.
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