derivative nucleoside
[/dɪˈrɪvətɪv ˈnjuːkliəsaɪd/]
nounpl: derivative nucleosides
nucleosídeo derivado
1. A modified nucleoside compound created by chemical alteration of a natural nucleoside, where one or more substituents are added or modified on the purine or pyrimidine base, the ribose or deoxyribose sugar, or both
The pharmaceutical company synthesized a derivative nucleoside with enhanced antiviral properties by modifying the 5-position of the cytosine base.
A empresa farmacêutica sintetizou um nucleosídeo derivado com propriedades antivirais aprimoradas ao modificar a posição 5 da base citosina.
2. In medicinal chemistry and biochemistry, a nucleoside analog or modified nucleoside used in drug development, particularly for antiviral and anticancer therapeutics
Derivative nucleosides like azidothymidine (AZT) have been crucial in HIV treatment regimens.
Nucleosídeos derivados como a azidotimidina (AZT) têm sido cruciais nos regimes de tratamento do HIV.
This term is primarily used in scientific and pharmaceutical contexts in both Brazil and the USA. It represents specialized vocabulary in biochemistry, medicinal chemistry, and pharmaceutical development. The term gained prominence following HIV/AIDS research in the 1980s-90s when derivative nucleosides became crucial therapeutic agents. Usage is consistent across Portuguese and English-speaking countries due to the universal nature of scientific nomenclature.
Related Idioms & Phrases
synthetic derivative nucleoside
rationally designed derivative nucleoside
structure-activity relationship of derivative nucleosides
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