nucleoside analog
[NOO-klee-uh-sahyd uh-NAL-ug]
nounpl: nucleoside analogs
análogo de nucleosídeo
1. A synthetic compound structurally similar to a natural nucleoside that can be incorporated into nucleic acids and is used as an antiviral or anticancer agent
Nucleoside analogs like azidothymidine (AZT) were among the first effective treatments for HIV infection.
Análogos de nucleosídeo como azidotimidina (AZT) foram entre os primeiros tratamentos eficazes para infecção por HIV.
2. A molecule that mimics the structure of a nucleoside but has modifications that disrupt normal nucleic acid synthesis in viruses or cancer cells
The nucleoside analog was designed to inhibit viral replication by preventing proper DNA chain elongation.
O análogo de nucleosídeo foi desenvolvido para inibir a replicação viral prevenindo o alongamento adequado da cadeia de DNA.
This is specialized scientific and medical terminology used primarily in pharmaceutical, virology, and oncology research. The term gained significant cultural prominence during the HIV/AIDS crisis in the 1980s-90s when nucleoside analogs became breakthrough treatments. It remains central to discussions of antiviral therapy in both Brazilian and American medical contexts.
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