central tolerance
[/ˈsentrəl ˈtɑːlərəns/]
nounpl: central tolerances
tolerância central
1. An immunological mechanism by which the immune system eliminates or inactivates self-reactive lymphocytes (T cells and B cells) in the thymus and bone marrow during their development, preventing autoimmune reactions against the body's own tissues
Central tolerance is crucial for preventing autoimmune diseases by eliminating lymphocytes that recognize self-antigens.
A tolerância central é crucial para prevenir doenças autoimunes eliminando linfócitos que reconhecem antígenos próprios.
2. The process of negative selection that occurs in primary lymphoid organs before lymphocytes enter circulation
The breakdown of central tolerance can lead to the development of autoimmune conditions such as lupus or rheumatoid arthritis.
O colapso da tolerância central pode levar ao desenvolvimento de condições autoimunes como lúpus ou artrite reumatoide.
Central tolerance is primarily a scientific and medical term with no cultural or colloquial variations. It is used uniformly in academic and clinical settings across Brazil, Portugal, and English-speaking countries. The concept is fundamental to immunology education and autoimmune disease research in all these regions.
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