self-antigen
[/ˈsɛlf ˈæntɪdʒən/]
nounpl: self-antigens
autoantigênio
1. An antigen that is a normal component of an organism's own body tissues, which can trigger an autoimmune response if the immune system fails to distinguish self from non-self
The body's immune system normally tolerates self-antigens to prevent autoimmune diseases.
O sistema imunológico do corpo normalmente tolera autoantigênios para prevenir doenças autoimunes.
2. In medical and immunological contexts, a molecule or structure derived from the host organism itself that can provoke an immune response in pathological conditions
In lupus, patients develop antibodies against self-antigens like DNA and histones.
No lúpus, os pacientes desenvolvem anticorpos contra autoantigênios como DNA e histonas.
This is specialized medical and immunological terminology used primarily in academic, clinical, and research settings. The term is essential in understanding autoimmune diseases, which are significant public health concerns in both Brazil and the USA. The concept of self-antigens is fundamental to modern immunology education and clinical diagnostics.
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