immune tolerance
[ɪˈmjuːn ˈtɒlərəns]
nounpl: immune tolerances
tolerância imunológica
1. The state in which the immune system does not mount a response against specific antigens or self-antigens, preventing autoimmune reactions and maintaining homeostasis.
Immune tolerance to self-antigens is essential for preventing autoimmune diseases.
A tolerância imunológica aos antígenos próprios é essencial para prevenir doenças autoimunes.
2. In transplantation medicine, the ability of the immune system to accept a foreign transplant without rejection.
The development of immune tolerance after organ transplantation reduces the need for lifelong immunosuppressive therapy.
O desenvolvimento de tolerância imunológica após transplante de órgão reduz a necessidade de terapia imunossupressora vitalícia.
3. The process by which immune cells are educated to recognize and ignore harmless substances or self-tissue.
Immune tolerance breaks down in autoimmune conditions like rheumatoid arthritis.
A tolerância imunológica falha em condições autoimunes como artrite reumatoide.
This is a highly specialized term used primarily in medical, immunological, and scientific research contexts in both Brazil and Portugal. It is essential terminology for healthcare professionals, researchers, and transplant specialists. The concept gained significant public awareness during vaccine development discussions and in discussions about autoimmune disease management. In Brazil, it's commonly referenced in discussions about organ transplantation programs and immunological research initiatives.
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