1. A substantial or considerable gift of money, goods, or services given to a person, organization, or cause
The foundation received a significant donation from a wealthy philanthropist.
A fundação recebeu uma doação significativa de um filantropo abastado.
2. A contribution that has meaningful impact or importance
His significant donation helped build the new hospital wing.
Sua doação significativa ajudou a construir a nova ala do hospital.