1. A significant and meaningful addition or gift that has deep impact or importance, often in academic, scientific, artistic, or social contexts
Her research made a profound contribution to the field of medicine.
Sua pesquisa fez uma contribuição profunda para o campo da medicina.
2. A deeply thoughtful or intellectually substantial input or participation
The author's profound contribution to literature will be remembered for generations.
A contribuição profunda do autor para a literatura será lembrada por gerações.