1. To complete or achieve something with great care, attention to detail, and effort, taking considerable time and dedication
She painstakingly accomplished the restoration of the ancient manuscript.
Ela realizou com esmero a restauração do manuscrito antigo.
2. To succeed in doing something difficult through persistent and meticulous work
They painstakingly accomplished their goal despite numerous obstacles.
Eles conseguiram com afinco seu objetivo apesar de inúmeros obstáculos.