1. An expression indicating that there are no problems, concerns, or difficulties with something
Can you help me move this weekend? No issues, I'm free.
Você pode me ajudar a me mudar neste fim de semana? Sem problemas, estou livre.
2. A casual affirmation that something is acceptable or can be done without any complications
Is it okay if I borrow your car? No issues at all.
Tudo bem se eu pegar seu carro emprestado? Nenhum problema.
3. Confirmation that one agrees with a suggestion or proposal without reservations
Let's meet at 3 PM tomorrow. No issues for me.
Vamos nos encontrar amanhã às 3 da tarde. Sem problemas para mim.