1. A significant or important fact; a piece of information or truth that has considerable importance or impact
A major fact in the case is that the witness was present at the scene.
Um fato importante no caso é que a testemunha estava presente no local.
2. A key or essential piece of evidence or information in an argument, discussion, or analysis
The major fact we must consider is that climate change affects global temperatures.
O fato importante que devemos considerar é que a mudança climática afeta as temperaturas globais.