1. to manage or deal with something in a careful, accountable, and ethical manner
You must handle responsibly the sensitive information entrusted to you.
Você deve lidar responsavelmente com as informações sensíveis que lhe foram confiadas.
2. to treat or use something with proper care and accountability
The company handles responsibly its environmental impact.
A empresa lida responsavelmente com seu impacto ambiental.