to take off; to unstick; to detach
1. (aviation) to lift off the ground; to become airborne
The airplane will take off at 3 PM.
O avião vai despegar às 3 da tarde.
2. to separate or detach something that is stuck or glued
I cannot unstick this label from the bottle.
Não consigo despegar este rótulo da garrafa.
3. (figurative) to progress; to succeed; to take off (as in a business or career)
Her singing career finally took off after years of struggling.
A carreira de cantora dela finalmente descolou após anos de luta.
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