decreasing efficacy
[/dɪˈkriːsɪŋ ɪˈfɪkəsi/]
noun phrase
eficácia decrescente
1. A progressive reduction in the effectiveness or ability of something to produce the desired result over time
The medication showed decreasing efficacy after six months of continuous use.
O medicamento mostrou eficácia decrescente após seis meses de uso contínuo.
2. In medical and pharmaceutical contexts, the phenomenon where a treatment becomes less effective with repeated applications or prolonged use
Tolerance led to decreasing efficacy of the antibiotic against the infection.
A tolerância levou à eficácia decrescente do antibiótico contra a infecção.
3. The gradual decline in performance or potency of a substance, device, or intervention
The pesticide exhibited decreasing efficacy due to pest resistance.
O pesticida apresentou eficácia decrescente devido à resistência das pragas.
This term is predominantly used in medical, pharmaceutical, and scientific contexts in both American English and Brazilian Portuguese. In Brazil, it's commonly discussed in healthcare settings regarding medication tolerance and in agriculture regarding pesticide resistance. The concept is particularly relevant in discussions of antibiotic resistance, a growing public health concern in both countries.
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