cross-tolerance
[/ˈkrɔːs ˈtɒlərəns/]
nounpl: cross-tolerances
tolerância cruzada
1. A pharmacological phenomenon in which tolerance developed to one drug results in reduced responsiveness to another drug, typically of the same class or with similar mechanisms of action
Cross-tolerance between different benzodiazepines means that tolerance to one drug may reduce the effectiveness of another.
A tolerância cruzada entre diferentes benzodiazepínicos significa que a tolerância a um medicamento pode reduzir a eficácia de outro.
2. The decreased effectiveness of a second substance due to prior exposure and adaptation to a structurally or functionally similar substance
Patients who develop cross-tolerance to opioids may require adjusted dosing when switching medications.
Pacientes que desenvolvem tolerância cruzada a opioides podem precisar de ajustes de dosagem ao mudar de medicamentos.
This is a specialized medical and pharmacological term used primarily in clinical, research, and pharmaceutical contexts. It is crucial in medical practice for understanding drug interactions and managing patient treatment, particularly in addiction medicine, pain management, and psychiatry. The concept is equally important in both Brazilian and Portuguese medical systems, as well as in English-speaking countries.
Related Idioms & Phrases
develop cross-tolerance to
exhibit cross-tolerance between
account for cross-tolerance
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