1. A pathological condition characterized by impaired function of high-density lipoprotein (HDL) cholesterol, reducing its ability to remove excess cholesterol from arteries and tissues, thereby increasing cardiovascular disease risk
HDL dysfunction can significantly increase the risk of atherosclerosis despite normal HDL cholesterol levels.
A disfunção do HDL pode aumentar significativamente o risco de aterosclerose, apesar dos níveis normais de colesterol HDL.
2. A metabolic disorder where HDL particles lose their protective anti-inflammatory and antioxidant properties
Recent studies show that HDL dysfunction is more prevalent in patients with metabolic syndrome.
Estudos recentes demonstram que a disfunção do HDL é mais prevalente em pacientes com síndrome metabólica.
HDL dysfunction is a medical term primarily used in cardiology and preventive medicine contexts. It has gained prominence in both American and Brazilian medical research as understanding of cholesterol quality versus quantity has evolved. The term reflects modern cardiovascular medicine's shift from simply measuring cholesterol levels to assessing functional capacity of lipoproteins in disease prevention.