1. Complete separation from others; a state of being completely alone or cut off from all contact with other people or groups
The prisoner was placed in total isolation for his own protection.
O prisioneiro foi colocado em isolamento total para sua própria proteção.
2. The condition of being completely removed from social, political, or economic connections
The country faced total isolation following the international sanctions.
O país enfrentou isolamento total após as sanções internacionais.
3. Complete separation of a person, object, or substance from all external influences or contamination
The laboratory maintained total isolation to prevent contamination of the samples.
O laboratório mantinha isolamento total para evitar contaminação das amostras.