1. Of considerable importance, size, or worth; substantial
The company made a sustancial investment in new technology.
A empresa fez um investimento substancial em nova tecnologia.
2. Having a solid basis in reality or fact; real and tangible
There is sustancial evidence supporting the theory.
Há evidência substancial apoiando a teoria.
3. Of or relating to the essential nature of something; fundamental
The sustancial differences between the two proposals are clear.
As diferenças substanciais entre as duas propostas são claras.