1. A significant or considerable obstacle that impedes progress, development, or the achievement of a goal
The lack of funding proved to be a substantial hindrance to the project's completion.
A falta de financiamento provou ser um obstáculo substancial para a conclusão do projeto.
2. A serious impediment or barrier that causes meaningful delay or difficulty
Language barriers can be a substantial hindrance in international business negotiations.
As barreiras linguísticas podem ser um obstáculo substancial nas negociações comerciais internacionais.