1. A significant, considerable, or major obstacle or challenge that requires substantial effort to overcome
The company faced substantial difficulty in meeting the new regulatory requirements.
A empresa enfrentou dificuldade substancial em atender aos novos requisitos regulatórios.
2. In legal or educational contexts, a significant impediment or functional limitation that substantially limits major life activities
Students with substantial difficulty in reading qualify for specialized accommodations.
Estudantes com dificuldade substancial em leitura se qualificam para acomodações especializadas.