1. An important, meaningful, or impactful piece of creative or intellectual output that has substantial value or influence
That novel is considered a significant work in modern literature.
Esse romance é considerado uma obra significativa na literatura moderna.
2. Work or labor that holds considerable importance or consequence in a particular context
The restoration of the cathedral was a significant work that took years to complete.
A restauração da catedral foi uma obra significativa que levou anos para ser concluída.