1. A substantial or considerable obstruction that impedes flow or movement, commonly used in medical contexts to describe narrowing of blood vessels or airways
The patient was diagnosed with a significant blockage in the left coronary artery.
O paciente foi diagnosticado com uma obstrução significativa na artéria coronária esquerda.
2. A notable obstruction in any passage, pipe, or channel that substantially reduces or prevents flow
There is a significant blockage in the drainage pipe that needs immediate attention.
Há uma obstrução significativa no cano de drenagem que precisa de atenção imediata.