signaling cascade
[ˈsɪɡ.nəl.ɪŋ ˈkæs.keɪd]
nounpl: signaling cascades
cascata de sinalização
1. A series of molecular events in which one protein activates another, which in turn activates a third protein, and so on, resulting in a cellular response to an external signal
The signaling cascade begins when a hormone binds to a cell surface receptor.
A cascata de sinalização começa quando um hormônio se liga a um receptor na superfície celular.
2. A biochemical pathway involving sequential activation of enzymes or proteins, typically involving phosphorylation events
Researchers studied the signaling cascade that leads to cell division.
Os pesquisadores estudaram a cascata de sinalização que leva à divisão celular.
3. A mechanism of signal transduction where multiple sequential steps amplify and propagate cellular signals
The MAPK signaling cascade is essential for cellular responses to growth factors.
A cascata de sinalização MAPK é essencial para as respostas celulares aos fatores de crescimento.
This term is primarily used in scientific and medical contexts in both Brazil and the United States. It is standard terminology in molecular biology, biochemistry, and cell biology courses and research. The concept is fundamental to understanding cellular communication, disease mechanisms, and pharmaceutical targets, making it essential vocabulary for scientists, researchers, and healthcare professionals in both countries.
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