1. To release or free someone or something from confinement, restraint, or control
The zookeeper is setting loose the birds from their cage.
O tratador do zoológico está soltando os pássaros da gaiola.
2. To allow someone to act without restriction or supervision
They set loose the dogs to guard the property.
Eles soltaram os cães para guardar a propriedade.
3. To unleash or release something intangible such as emotions, creativity, or forces
The artist set loose her imagination on the canvas.
A artista soltou sua imaginação na tela.