1. A bite or sting from an insect (particularly a mosquito) on skin that has never been bitten before by that species, resulting in a more pronounced allergic reaction or swelling
The mosquito's virgin bite on her arm caused severe itching and swelling.
A picada virgem do mosquito em seu braço causou coceira e inchaço severos.
2. In a broader sense, a first encounter with something that causes irritation or harm
His virgin bite of criticism from the press was particularly harsh.
Sua picada virgem de crítica da imprensa foi particularmente severa.