nondisjunction
[/ˌnɑːndɪsˈdʒʌŋkʃən/]
nounpl: nondisjunctions
não-disjunção
1. The failure of chromosomes or chromatids to separate properly during cell division (meiosis or mitosis), resulting in an unequal distribution of genetic material to daughter cells.
Nondisjunction during meiosis can result in gametes with an abnormal number of chromosomes.
A não-disjunção durante a meiose pode resultar em gametas com um número anormal de cromossomos.
2. A cytogenetic event that leads to aneuploidy in the resulting cells or offspring.
Down syndrome is often caused by nondisjunction of chromosome 21.
A síndrome de Down é frequentemente causada pela não-disjunção do cromossomo 21.
This is a technical term primarily used in genetics, cytology, and medical contexts. It is consistently used across both Brazilian Portuguese and European Portuguese scientific communities. The term is essential in understanding chromosomal abnormalities and genetic disorders. In both American and Brazilian educational systems, it is taught as a key concept in cell biology and genetics courses.
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