1. A melody or tune that has been forgotten, is no longer played, or has been lost to time
The composer spent years searching for the lost melody from his childhood.
O compositor passou anos procurando pela melodia desaparecida da sua infância.
2. A metaphorical reference to something beautiful or meaningful that has been forgotten or abandoned
Like a lost melody, their friendship faded into silence.
Como uma melodia desaparecida, a amizade deles desapareceu no silêncio.