1. The usual or customary path, course, or sequence of stops on a journey, typically followed by public transportation or regular travel services
The bus will follow its normal itinerary despite the roadwork.
O ônibus seguirá seu itinerário normal apesar das obras na rua.
2. The regular planned schedule or sequence of destinations for a tour, trip, or journey
The tour operator deviated from the normal itinerary due to weather conditions.
A operadora de turismo se desviou do itinerário normal devido às condições climáticas.