1. In a way that cannot be remedied, cured, or fixed; beyond repair or recovery
The damage to the building was irremediably compromised by the fire.
O dano ao edifício foi irremediavelmente comprometido pelo incêndio.
2. Inevitably; in a way that cannot be avoided or undone
His reputation was irremediably tarnished by the scandal.
Sua reputação foi irremediavelmente manchada pelo escândalo.