1. in actual reality, as opposed to online, in imagination, or in a fictional context
She's funny online, but in real life she's quite shy.
Ela é engraçada online, mas na vida real ela é bem tímida.
2. in practice or actuality, as opposed to theory
In real life, things rarely work out as perfectly as planned.
Na vida real, as coisas raramente funcionam tão perfeitamente quanto planejado.