holoenzyme
[/ˈhɒloʊˌɛnzaɪm/]
nounpl: holoenzymes
holoenzima
1. A complete, fully functional enzyme consisting of a protein component (apoenzyme) bound to its required non-protein cofactor or coenzyme
The holoenzyme becomes catalytically active only when the metal cofactor is properly bound to the apoenzyme.
A holoenzima torna-se cataliticamente ativa apenas quando o cofator metálico está adequadamente ligado à apoproteína.
2. An enzyme in its native, active form as opposed to its inactive protein component alone
The pyruvate dehydrogenase holoenzyme requires thiamine pyrophosphate as an essential cofactor.
A holoenzima piruvato desidrogenase requer pirofosfato de tiamina como cofator essencial.
Holoenzyme is a technical term primarily used in academic and professional biochemistry contexts. It appears frequently in university-level biochemistry courses, research publications, and clinical laboratory settings in both Brazil and the USA. The term is consistently used across both countries without regional variation, as it is part of international scientific nomenclature.
Look up more words on Fala2Me
The free English-Portuguese dictionary with real Brazilian accents, NYC slang, conjugator and more
Open Fala2Me →