1. To deviate from the intended path or direction, either literally (navigation) or figuratively (plans, goals)
The ship went off-course due to strong winds.
O navio saiu do rumo devido aos ventos fortes.
2. To stray from a planned course of action or schedule
Our project went off-course when we lost our main investor.
Nosso projeto saiu do rumo quando perdemos nosso principal investidor.