1. to become acquainted with something through study or experience; to gain knowledge or understanding of something
I need to familiarize myself with the new software before the meeting.
Preciso familiarizar-me com o novo software antes da reunião.
2. to make oneself knowledgeable or comfortable with a subject, place, or person
She spent the first week familiarizing herself with the city.
Ela passou a primeira semana familiarizando-se com a cidade.