1. An informal, casual, or intimate manner of speaking, behaving, or interacting with someone
They greeted each other in a familiar way, as old friends do.
Eles se cumprimentaram de um modo familiar, como velhos amigos fazem.
2. A manner of communication or behavior that shows ease and comfort with someone
She spoke to him in a familiar way that surprised everyone.
Ela falou com ele de um jeito familiar que surpreendeu a todos.