1. Rules, principles, or standards that have been formally set up and are widely accepted or recognized
We must follow the established guidelines for safety procedures in the workplace.
Devemos seguir as diretrizes estabelecidas para os procedimentos de segurança no local de trabalho.
2. Predetermined instructions or recommendations that are official and binding
The research project must comply with the established guidelines of the ethics committee.
O projeto de pesquisa deve estar em conformidade com as diretrizes estabelecidas do comitê de ética.