1. The main or principal department of an organization, company, or institution, typically where executive decisions are made and administrative functions are centralized
The company's headquarters department is located in downtown São Paulo.
O departamento sede da empresa fica no centro de São Paulo.
2. The central administrative office from which a branch or divisional structure is managed
All regional offices report to the headquarters department.
Todos os escritórios regionais reportam ao departamento sede.