1. A change or alteration that affects the fundamental nature, structure, or essential properties of something; a modification that is inherent or integral to the composition or constitution of an entity
The constitutive modification of the protein structure altered its biological function.
A modificação constitutiva da estrutura proteica alterou sua função biológica.
2. In linguistics and genetics, a permanent or structural change that becomes part of the essential makeup of a system, organism, or language
Constitutive modifications in gene expression lead to permanent phenotypic changes.
As modificações constitutivas na expressão gênica levam a mudanças fenotípicas permanentes.