1. A case, situation, or condition that has progressed to a more severe, developed, or complex stage
The patient presented with an advanced case of diabetes.
O paciente apresentava um caso avançado de diabetes.
2. In legal or administrative contexts, a matter that has progressed significantly in proceedings
The lawsuit was already an advanced case when we took it on.
O processo era já um caso avançado quando o assumimos.
3. A situation or problem that has reached a critical or late stage of development
The disease had reached an advanced case requiring immediate intervention.
A doença tinha atingido um caso avançado que exigia intervenção imediata.