1. To prevent or obstruct the reaching of a final decision, agreement, or outcome
The senator's filibuster was designed to block the conclusion of the debate.
O discurso obstrucionista do senador foi projetado para bloquear a conclusão do debate.
2. To impede the finalization of a process, negotiation, or agreement
New evidence could block the conclusion of the investigation.
Novas evidências poderiam bloquear a conclusão da investigação.